Article
Mutations in the embB locus among Korean clinical isolates of Mycobacterium tuberculosis resistant to ethambutol.
Yonsei medical journal - 1 Feb 2002
Lee Hye Young, Myoung Han Jung, Bang Hye Eun, Bai Gill-Han, Kim Sang-Jae, Kim Joo Deuk, Cho Sang-Nae
Abstract excerpt
Resistance of Mycobacterium tuberculosis to ethambutol (EMB) has been assigned to an operon, embCAB, which has been proposed to be a structural gene for mycobacterial arabinosyl transferases. Recently, genetic events resulting in structural mutations at embB have been proposed as major contributors to the EMB-resistance of isolates whose minimum inhibitory concentration (MIC) level is higher than 20 microgram/ml....
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