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Article

The implications of mutations in multiple genes associated with ethambutol resistance among multidrug-resistant tuberculosis isolates from China.

BMC microbiology - 1 Mar 2025

Li Ma-Chao, Wang Wei, Xiao Tong-Yang, Liu Hai-Can, Lin Shi-Qiang, Hang Hao, Bo Xiang-Long, Nan Xiao-Tian, Qian Cheng, Fan Xue-Ting, Zhao Xiu-Qin, Li Gui-Lian, Wan Kang-Lin, Zhao Li-Li

Abstract excerpt

OBJECTIVES: To assess the mutation effects of ethambutol (EMB) resistance-associated genes, including embCAB operon, ubiA, embR, and aftA, on the EMB resistance levels among multidrug-resistant tuberculosis (MDR-TB) isolates from China. METHODS: A total of 159 MDR-TB from China had their EMB MICs quantified, and the sequences of the four ethambutol resistance-associated regions were analyzed. A multivariate...

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Identifiers

PMID: 40025456
DOI: 10.1186/s12866-025-03821-y
PMCID: PMC11871839

Genes

EMB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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