Article
Polymorphisms in Rv3806c (ubiA) and the upstream region of embA in relation to ethambutol resistance in clinical isolates of Mycobacterium tuberculosis from North India.
Tuberculosis (Edinburgh, Scotland) - 1 Jan 2018
Giri Astha, Gupta Shraddha, Safi Hassan, Narang Anshika, Shrivastava Kamal, Kumar Sharma Naresh, Lingaraju Subramanya, Hanif Mahmud, Bhatnagar Anuj, Menon Balakrishnan, Alland David, Varma-Basil Mandira
Abstract excerpt
Mutations at embB306 are the most prevalent polymorphisms associated with ethambutol (EMB) resistance, responsible for 40-60% of EMB resistant clinical cases of tuberculosis (TB). The present study analyzed additional mutations associated with EMB resistance in the embB, embC, embA and Rv3806c (ubiA) genes in 29 EMB resistant and 29 EMB susceptible clinical isolates of M. tuberculosis selected from 360 patients...
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