Article

Mutations in the <i>ubiA</i> gene are the major mechanism of ethambutol resistance in <i>Mycobacterium avium</i>

2025-09-27

Abstract excerpt

<h4>ABSTRACT</h4> Mycobacterium avium-intracellulare complex (MAC) infections are the most common nontuberculous mycobacterial (NTM) infections, and ethambutol (EMB) is one of the main therapeutic agents used to treat MAC infections. However, the EMB resistance profile and its resistance mechanisms in M. avium remain poorly understood. This study determined the minimum inhibitory concentration (MIC) on 40 M. av...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 064e758c-b963-5136-aa5d-f89097427a32
DOI: 10.1101/2025.09.27.678926

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutations in the <i>ubiA</i> gene are the major mechanism of ethambutol resistance in <i>Mycobacterium avium</i>DOI 10.1101/2025.09.27.678926Read

ubiA (Rv3806c) encoding DPPR synthase involved in cell wall synthesis is associated with ethambutol resistance in Mycobacterium tuberculosis.Semantic proximity Read

Mutations in <i>emb</i> B406 are associated with low-level ethambutol resistance in Canadian <i>Mycobacterium tuberculosis</i> isolatesSemantic proximity Read

Molecular Mechanisms Underlying Antimicrobial Resistance in Mycobacteria.Semantic proximity Read

Molecular Genetic Analysis of Nucleotide Polymorphisms Associated with Ethambutol Resistance in Human Isolates of <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Mutations Found in<i>embCAB</i>,<i>embR</i>, and<i>ubiA</i>Genes of Ethambutol-Sensitive and -Resistant<i>Mycobacterium tuberculosis</i>Clinical Isolates from ChinaSemantic proximity Read

Genetic determinants of intrinsic antibiotic tolerance in <i>Mycobacterium avium</i>Semantic proximity Read

The role of epistasis in amikacin, kanamycin, bedaquiline, and clofazimine resistance in <i>Mycobacterium tuberculosis</i> complexSemantic proximity Read

Identification of Novel Mutations Causing Clofazimine Resistance in <i>Mycobacterium intracellulare</i>Semantic proximity Read

Geographic Differences in the Contribution of ubiA Mutations to High-Level Ethambutol Resistance in Mycobacterium tuberculosis.Semantic proximity Read

<i>In host</i> mutational adaptation of <i>Mycobacterium tuberculosis</i> complex strainsSemantic proximity Read

Ethambutol resistance in <i>Mycobacterium avium-intracellulare</i> is associated with mutations in the <i>embA–embB</i> promoter and <i>embB</i>Semantic proximity Read

Genome wide analyses reveal the role of mutator phenotypes in the emergence of drug resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read