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Article

Mutations within embCAB Are Associated with Variable Level of Ethambutol Resistance in Mycobacterium tuberculosis Isolates from China.

Antimicrobial agents and chemotherapy - 1 Jan 2018

Sun Qing, Xiao Tong-Yang, Liu Hai-Can, Zhao Xiu-Qin, Liu Zhi-Guang, Li Ya-Nan, Zeng Hao, Zhao Li-Li, Wan Kang-Lin

Abstract excerpt

The EmbCAB proteins have been considered a target for ethambutol (EMB). Mutations in embCAB are known to confer most EMB resistance. However, the knowledge about the effects of embCAB mutations on the EMB resistance level and about the role of mutation-mutation interactions is limited in China. Here, we sequenced embCAB among 125 Mycobacterium tuberculosis isolates from China and quantified their EMB MICs by...

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Identifiers

PMID: 29084750
DOI: 10.1128/AAC.01279-17
PMCID: PMC5740351

Genes

EMB

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Mutations within embCAB Are Associated with Variable Level of Ethambutol Resistance in Mycobacterium tuberculosis Isolates from China.PMID 29084750Read ↗

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