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Article

Mutations in the <i>embC-embA</i> Intergenic Region Contribute to Mycobacterium tuberculosis Resistance to Ethambutol

3 Sept 2014

Abstract excerpt

The rapid increase in Mycobacterium tuberculosis resistance to ethambutol (EMB) threatens the diagnosis and treatment of tuberculosis (TB). We investigated the role of mutations in the embC-embA intergenic region (IGR) in EMB-resistant clinical strains from east China. A total of 767 M. tuberculosis clinical strains were collected and analyzed for their drug susceptibility to EMB using the MGIT 960 system and MIC...

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PMID: 25182646
DOI: 10.1128/aac.03285-14

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