Article

TCR meta-clonotypes for biomarker discovery with tcrdist3: identification of public, HLA-restricted SARS-CoV-2 associated TCR features

2020-12-26

Abstract excerpt

<h4>ABSTRACT</h4> As the mechanistic basis of adaptive cellular antigen recognition, T cell receptors (TCRs) encode clinically valuable information that reflects prior antigen exposure and potential future response. However, despite advances in deep repertoire sequencing, enormous TCR diversity complicates the use of TCR clonotypes as clinical biomarkers. We propose a new framework that leverages antigen-enriched...

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Literature Corpus work: 4dcc0de8-373b-52fb-a178-8193bdf3ff86
DOI: 10.1101/2020.12.24.424260

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