Article

BenchRep-T: A Systematic Evaluation of T-Cell Repertoire-Based Disease Diagnostics

2026-06-10

Abstract excerpt

Adaptive immune receptor repertoire sequencing data has emerged as a promising potential modality for disease diagnosis, relying on computational methods to analyze T-cell receptor (TCR) sequences from an individual’s blood sample. Published methods rely on different cohorts, data preprocessing pipelines, and evaluation metrics, making direct comparison across methods challenging. We present BenchRep-T, a unified...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 547e2294-bb6a-5d44-acc2-32c1ddf6ac51
DOI: 10.64898/2026.06.09.727013

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

BenchRep-T: A Systematic Evaluation of T-Cell Repertoire-Based Disease DiagnosticsDOI 10.64898/2026.06.09.727013Read

UcTCRp: a TCRβ-based framework for quantitative MAIT- and iNKT-associated repertoire-state profilingSemantic proximity Read

Disease associated human TCR characterization by deep-learning framework TCR-DeepInsightSemantic proximity Read

Machine learning identifies T cell receptor repertoire signatures associated with COVID-19 severitySemantic proximity Read

Platypus: an open-access software for integrating lymphocyte single-cell immune repertoires with transcriptomesSemantic proximity Read

Detecting T-cell receptors involved in immune responses from single repertoire snapshotsSemantic proximity Read

HuBIE: The Human Blood Immunome Encyclopedia Of TCRs and BCRs in Bloodstream Infections and CancerSemantic proximity Read

DeepTCR: a deep learning framework for understanding T-cell receptor sequence signatures within complex T-cell repertoiresSemantic proximity Read

TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs.Semantic proximity Read

T cell receptor repertoire signatures associated with COVID-19 severitySemantic proximity Read

Disease diagnostics using machine learning of B cell and T cell receptor sequencesSemantic proximity Read

Inference of SARS-CoV-2 exposure biomarkers using large-scale T-cell repertoire profilingSemantic proximity Read

T-Cell Receptor Repertoire Sequencing and Its Applications: Focus on Infectious Diseases and CancerSemantic proximity Read