Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing.

Molecular biology of the cell - 1 Apr 2006

Clarke Astrid S, Samal Eva, Pillus Lorraine

Abstract excerpt

Among acetyltransferases, the MYST family enzyme Esa1p is distinguished for its essential function and contribution to transcriptional activation and DNA double-stranded break repair. Here we report that Esa1p also plays a key role in silencing RNA polymerase II (Pol II)-transcribed genes at telomeres and within the ribosomal DNA (rDNA) of the nucleolus. These effects are mediated through Esa1p's HAT activity and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Fungal
Share to Histone Acetyltransferases
Share to Histone Deacetylases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

Share to Sirtuin 2

Share to Sirtuins

Share to Tandem Repeat Sequences

Share to Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 16436512
DOI: 10.1091/mbc.e05-07-0613
PMCID: PMC1415314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing.PMID 16436512Read ↗

Esa1p is an essential histone acetyltransferase required for cell cycle progression.Semantic proximity Read ↗

Bypassing the requirement for an essential MYST acetyltransferase.Semantic proximity Read ↗

Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast.Semantic proximity Read ↗

Diversity in the Sir2 family of protein deacetylasesSemantic proximity Read ↗

Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing.Semantic proximity Read ↗

Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing.Semantic proximity Read ↗

Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription.Semantic proximity Read ↗

The Sir2 Family of Protein DeacetylasesSemantic proximity Read ↗

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.Semantic proximity Read ↗

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon controlSemantic proximity Read ↗

A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation.Semantic proximity Read ↗

Crystal structure of yeast Esa1 suggests a unified mechanism for catalysis and substrate binding by histone acetyltransferases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.