Article

Epigenetic lockdown of type I interferon sensing and signalling in human pluripotent cells

2025-10-27

Abstract excerpt

The Human Silencing Hub (HUSH) complex safeguards genome integrity in human somatic cells by repressing transposable elements and regulating type I interferon (IFN-I) induction. In early development, the IFN-I pathway is inactive, yet its underlying regulation is poorly understood. Here, we use depletion of the HUSH complex in human induced pluripotent stem cells (iPSCs) as a tool to investigate epigenetic control...

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Literature Corpus work: b6ec1c0a-b294-55c3-8e37-82bc90cfd1e2
DOI: 10.1101/2025.10.27.684762

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