Article

DNA methylation governs the sensitivity of repeats to restriction by the HUSH-MORC2 corepressor

2023-06-22

Abstract excerpt

<h4>ABSTRACT</h4> The human silencing hub (HUSH) complex binds to transcripts of LINE-1 retrotransposons (L1s) and other genomic repeats, recruiting MORC2 and other effectors to remodel chromatin. However, how HUSH and MORC2 operate alongside DNA methylation, a central epigenetic regulator of repeat transcription, remains poorly understood. Here we interrogate this relationship in human neural progenitor cells (h...

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Literature Corpus work: b225dc73-d3c2-585f-8b74-3bdb69d1474d
DOI: 10.1101/2023.06.21.545516

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