Article

Intrinsic immunity against HAdV is achieved by a novel epigenetic silencing complex

2025-02-10

Abstract excerpt

The DNA double-stranded genome of human adenoviruses (HAdV) is preferentially targeted by host factors involved in chromatin remodeling, such as SPOC1 and KAP1 to inhibit efficient viral gene expression. HAdV genomes undergo alterations through association with host histones and epigenetic modifications; however, the precise underlying mechanism remains elusive. A recently discovered silencing mechanism for retrot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9d970ff-4dfa-591f-a468-4e72610ce66c
DOI: 10.1101/2025.02.10.637372

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Intrinsic immunity against HAdV is achieved by a novel epigenetic silencing complexDOI 10.1101/2025.02.10.637372Read

SPOC1-Mediated Antiviral Host Cell Response Is Antagonized Early in Human Adenovirus Type 5 InfectionSemantic proximity Read

PRC1.6 localizes on chromatin with the human silencing hub (HUSH) complex for promoter-specific silencingSemantic proximity Read

Endogenous retrovirus activation: potential for immunology and clinical applicationsSemantic proximity Read

The adenovirus DNA-binding protein DBPSemantic proximity Read

Human Adenovirus Gene Expression and Replication Is Regulated through Dynamic Changes in Nucleoprotein Structure throughout InfectionSemantic proximity Read

Genome-wide CRISPR screenings identified SMCHD1 as a host-restricting factor for AAV transductionSemantic proximity Read

Human cytomegalovirus regulates host DNA repair machinery for viral genome integritySemantic proximity Read

The HUSH-SETDB1-MORC2 epigenetic repressor complex restricts herpesvirus infection in association with PML nuclear bodiesSemantic proximity Read

The Chromatin Landscape of Kaposi’s Sarcoma-Associated HerpesvirusSemantic proximity Read

The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin stateSemantic proximity Read

Interplay between Two Paralogous Human Silencing Hub (HuSH) Complexes in Regulating LINE-1 Element SilencingSemantic proximity Read

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon controlSemantic proximity Read