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Article

Mouse models of nesprin-related diseases.

Biochemical Society transactions - 19 Jun 2018

Zhou Can, Rao Li, Warren Derek T, Shanahan Catherine M, Zhang Qiuping

Abstract excerpt

Nesprins (nuclear envelope spectrin repeat proteins) are a family of multi-isomeric scaffolding proteins. Nesprins form the LInker of Nucleoskeleton-and-Cytoskeleton (LINC) complex with SUN (Sad1p/UNC84) domain-containing proteins at the nuclear envelope, in association with lamin A/C and emerin, linking the nucleoskeleton to the cytoskeleton. The LINC complex serves as both a physical linker between the nuclear...

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PMID: 29784648
DOI: 10.1042/BST20180085

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