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Article

Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle.

The Journal of cell biology - 3 Jul 2017

Stroud Matthew J, Feng Wei, Zhang Jianlin, Veevers Jennifer, Fang Xi, Gerace Larry, Chen Ju

Abstract excerpt

The position of the nucleus in a cell is controlled by interactions between the linker of nucleoskeleton and cytoskeleton (LINC) complex and the cytoskeleton. Defects in nuclear positioning and abnormal aggregation of nuclei occur in many muscle diseases and correlate with muscle dysfunction. Nesprin 1, which includes multiple isoforms, is an integral component of the LINC complex, critical for nuclear...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28533284
DOI: 10.1083/jcb.201612128
PMCID: PMC5496623

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