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Article

Nesprin-1/2: roles in nuclear envelope organisation, myogenesis and muscle disease.

Biochemical Society transactions - 17 Apr 2018

Zhou Can, Rao Li, Shanahan Catherine M, Zhang Qiuping

Abstract excerpt

Nesprins (nuclear envelope spectrin repeat proteins) are multi-isomeric scaffolding proteins. Nesprin-1 and -2 are highly expressed in skeletal and cardiac muscles and together with SUN (Sad1p/UNC84) domain-containing proteins form the LInker of Nucleoskeleton and Cytoskeleton (LINC) complex at the nuclear envelope in association with lamin A/C and emerin. Mutations in nesprin-1/2 have been found in patients with...

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Identifiers

PMID: 29487227
DOI: 10.1042/BST20170149

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