Article

Ninein domains required for its localization, association with partners dynein and ensconsin, and microtubule organization

2023-06-22

Abstract excerpt

Ninein (Nin) is a microtubule (MT) anchor at the subdistal appendages of mother centrioles and the pericentriolar material (PCM) of centrosomes that also functions to organize microtubules at non-centrosomal microtubule-organizing centers (ncMTOCs). In humans, the NIN gene is mutated in Seckel syndrome, an inherited developmental disorder. Here we dissect the protein domains involved in Nin’s localization and int...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 38fbe95e-9f88-5b04-9a3d-7b07913c7ffe
DOI: 10.1101/2023.06.22.546109

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ninein domains required for its localization, association with partners dynein and ensconsin, and microtubule organizationDOI 10.1101/2023.06.22.546109Read

The Seckel syndrome and centrosomal protein Ninein localizes asymmetrically to stem cell centrosomes but is not required for normal development, behavior, or DNA damage response in<i>Drosophila</i>Semantic proximity Read

The microtubule-binding protein ensconsin is an essential cofactor of kinesin-1.Semantic proximity Read

Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype.Semantic proximity Read

Cargo recognition of Nesprin-2 by the dynein adapter Bicaudal D2 for a nuclear positioning pathway that is important for brain developmentSemantic proximity Read

Microtubule plus-end tracking proteins in neuronal development.Semantic proximity Read

Regulation of outer kinetochore Ndc80 complex-based microtubule attachments by the central kinetochore Mis12/MIND complex.Semantic proximity Read

Mouse models of nesprin-related diseases.Semantic proximity Read

Mask, the <i>Drosophila</i> Ankyrin Repeat and KH domain-containing protein, regulates microtubule dynamicsSemantic proximity Read

Adaptable centriole biogenesis via the intrinsically disordered protein ALMS1Semantic proximity Read

Dynein regulates epithelial polarity and the apical localization of stardust A mRNA.Semantic proximity Read

Proximity-dependent proteomics reveals extensive interactions of Protocadherin-19 with regulators of Rho GTPases and the microtubule cytoskeletonSemantic proximity Read

A spectraplakin is enriched on the fusome and organizes microtubules during oocyte specification in Drosophila.Semantic proximity Read