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Article

TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.

Journal of cell science - 15 Oct 2008

Nery Flávia C, Zeng Juan, Niland Brian P, Hewett Jeffrey, Farley Jonathan, Irimia Daniel, Li Yuqing, Wiche Gerhard, Sonnenberg Arnoud, Breakefield Xandra O

Abstract excerpt

A specific mutation (DeltaE) in torsinA underlies most cases of the dominantly inherited movement disorder, early-onset torsion dystonia (DYT1). TorsinA, a member of the AAA+ ATPase superfamily, is located within the lumen of the nuclear envelope (NE) and endoplasmic reticulum (ER). We investigated an association between torsinA and nesprin-3, which spans the outer nuclear membrane (ONM) of the NE and links it to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18827015
DOI: 10.1242/jcs.029454
PMCID: PMC3539201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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