Article
Nesprins: intracellular scaffolds that maintain cell architecture and coordinate cell function?
Expert reviews in molecular medicine - 13 Jun 2005
Warren Derek T, Zhang Qiuping, Weissberg Peter L, Shanahan Catherine M
Abstract excerpt
Nesprins are a recently discovered family of ubiquitously expressed intracellular proteins. Through alternative transcriptional initiation, termination and splicing, two genes - nesprin-1 and nesprin-2 (also known as syne-1 and syne-2) - give rise to many protein isoforms that vary markedly in size. The largest of these isoforms comprise a C-terminal transmembrane domain (the KLS domain) linked by a...
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