Article

Bistable attractor dynamics in difficult-to-treat rheumatic disease: a multi-axis ODE framework with cross-disease transcriptomic evidence

2026-04-06

Abstract excerpt

Difficult-to-treat (D2T) rheumatic disease affects approximately 12% of rheumatoid arthritis patients and resists sequential biologic therapy, yet no mechanistic model explains this refractoriness as a system-level phenomenon. Here we present the 3-Axis Integrative Framework (3-AIF), a six-variable ordinary differential equation system integrating mucosal tolerance, energy-gated neuroimmune danger sensing, and int...

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Literature Corpus work: a99bad80-d304-5ec4-a426-3020d12f66ce
DOI: 10.64898/2026.04.02.716225

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