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The Perfect Storm Framework: A Testable Multi-Hit Model Linking Connective Tissue Variance, Neurodivergence, and Gene–Environment Interaction in Complex Chronic Illness

2026-08-04

Abstract excerpt

<p>Individuals with joint hypermobility and neurodivergent traits (autism, ADHD) show markedly elevated rates of psychiatric, autonomic and multi-system complaints, yet no single causal pathway has been established. We propose the Perfect Storm Framework: a multi-hit, threshold-based model in which constitutional connective-tissue and neurodevelopmental variance interacts multiplicatively, not additively, with dis...

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Literature Corpus work
0e26cc6b-c80a-58cc-880a-34be220754d2
DOI
10.31234/osf.io/upvk3_v1
Open publication

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