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Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing

3 Jan 2025

Abstract excerpt

Background: Anti-citrullinated peptide antibodies (ACPA)-negative (ACPA-) rheumatoid arthritis (RA) presents significant diagnostic and therapeutic challenges due to the absence of specific biomarkers, underscoring the need to elucidate its distinctive cellular and metabolic profiles for more targeted interventions. Methods: Single-cell RNA sequencing data from peripheral blood mononuclear cells (PBMCs) and...

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PMID: 39830504
DOI: 10.3389/fimmu.2024.1512483

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