Article

Co-evolved Partners of Immunity: A Trait-Based Map of Human Keystone Organisms

2025-08-23

Abstract excerpt

Persistent human-adapted microbes can act as immunological “keystones,” organizing host defense across tissues and shaping vulnerability under immune perturbation. More generally, tissue immunity is calibrated by persistent niche-resident organisms that tune compartment-specific thresholds of cytotoxicity and peripheral tolerance; keystone organisms represent the apex subset with multi-niche scope. Here we operati...

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Literature Corpus work: 7dd095d8-4772-527d-b00d-eec3f2b2f5b2
DOI: 10.1101/2025.08.19.671142

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