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Disease as Hysteresis: Agentic AI and VAE Latent Space Analysis Uncover Irreversible State Transitions in Periodontal Tissue

2026-03-31

Abstract excerpt

Chronic periodontitis represents one of the most prevalent inflammatory tissue-destructive conditions in humans, yet the molecular thresholds separating reversible inflammation from permanent structural collapse remain undefined. Using single-cell RNA sequencing data from 12,104 cells (GSE152042) spanning three disease states — healthy gingival tissue, mild periodontitis, and severe periodontitis — we constructed...

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Literature Corpus work
81083ca1-667b-549c-804a-9d1592f3781c
DOI
10.64898/2026.03.27.714684
Open publication

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