Article

Excitability as a Design Principle in the Immune System

2025-09-02

Abstract excerpt

Growing datasets and mechanistic detail in immunology have outpaced the development of unifying concepts. Such concepts are required to explain the primary goals of immune circuits - strong response to pathogens, tolerance to self, and prevention of collateral damage. A principle that achieves these goals across diverse immune circuits could unify our understanding of the immune system. Here, we propose that excit...

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Literature Corpus work: cb4decf6-7789-51b8-b68e-afd1f5e2f502
DOI: 10.1101/2025.08.31.673412

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