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Toward a Unified Conceptual Framework for Flare–Remission Dynamics in Autoimmune Diseases: A Treg–Tpex Oscillation and Dual-Threshold Model

2026-06-11

Abstract excerpt

Autoimmune diseases (AIDs) are characterized by recurrent flare–remission cycles, yet a unifying explanation for these dynamics remains lacking. Here, we propose a conceptual framework in which peripheral tolerance is maintained through dynamic interactions between regulatory T cells (Treg) and stem‑like autoreactive T cells (here termed Tpex‑like cells). In this model, clinical flares arise as dual‑threshold phas...

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Identifiers and source

Literature Corpus work
3fb33306-91a7-515c-bb80-2e2d8c7e9ef3
DOI
10.20944/preprints202606.0943.v1
Open publication

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Toward a Unified Conceptual Framework for Flare–Remission Dynamics in Autoimmune Diseases: A Treg–Tpex Oscillation and Dual-Threshold ModelDOI 10.20944/preprints202606.0943.v1
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