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Inflammatory Burden–Driven Bistability of Maternal–Fetal Immune Tolerance: A Framework for Pregnancy Complications

2026-06-19

Abstract excerpt

Maternal–fetal immune tolerance requires controlled immune quiescence toward the semi‑allogeneic fetus while preserving host defense. However, a static immunosuppression model does not fully explain key clinical phenomena, including heterogeneous pregnancy outcomes, abrupt onset of preeclampsia, and transient postpartum autoimmune activation. We propose a bistable dynamical framework in which maternal–fetal immuni...

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Literature Corpus work
1baad3f2-ae56-56af-9fb1-9bb47dc92ecd
DOI
10.20944/preprints202606.1469.v1
Open publication

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