Article

Identifying Integrative Molecular Pathways for Predictive Modeling of Infectious Disease

2019-11-08

Abstract excerpt

The signs and symptoms of infectious disease are similar in presentation, such as fever and fatigue, but differ in magnitude, duration, and sequence. Although observable responses of dysfunction are well characterized, the integrative system mechanisms driving such trajectories are poorly known, even during normative circumstances. Here, molecular pathways are presented that enable predictive modeling of autonomic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 80912f22-dda9-5f3c-ab3b-4407b556c146
DOI: 10.1101/835546

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identifying Integrative Molecular Pathways for Predictive Modeling of Infectious DiseaseDOI 10.1101/835546Read

Molecular Pathways Resultant in Fever due to Inhibitory Effects of Binding PGE2 to Glucocorticoid ReceptorsSemantic proximity Read

Dynamics and Internal Control of Body Temperature in Response to Infectious Agents and Other Causal FactorsSemantic proximity Read

Dexamethasone is a gold weapon for immunomodulation in severe COVID-19 but has no effect on endocrine interleukin 6 and sex-linked response the problem – In silico studySemantic proximity Read

Functional characterization of SARS-CoV-2 infection suggests a complex inflammatory response and metabolic alterationsSemantic proximity Read

A simple model of COVID-19 explains disease severity and the effect of treatmentsSemantic proximity Read

Gastrointestinal barrier disruption in Post-COVID Syndrome Fatigue patientsSemantic proximity Read

Bistable attractor dynamics in difficult-to-treat rheumatic disease: a multi-axis ODE framework with cross-disease transcriptomic evidenceSemantic proximity Read

Systems medicine approaches for the definition of complex phenotypes in chronic diseases and ageing. From concept to implementation and policies.Semantic proximity Read

The physio-affective symptoms of Long COVID are strongly predicted by the severity of the acute infectious phase, and lowered antioxidants, nitric oxide, and alanine transaminase levelsSemantic proximity Read

Stress-Related and Circadian Secretion and Target Tissue Actions of Glucocorticoids: Impact on HealthSemantic proximity Read

Primary Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes: A 2021 UpdateSemantic proximity Read

Intrinsic factors in the pathogenesis of hidradenitis suppurativa: Genetics, hormones, and the microbiomeSemantic proximity Read