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Article

Assembly of recombinant tau into filaments identical to those of Alzheimer’s disease and chronic traumatic encephalopathy

2021-12-17

Abstract excerpt

Abundant filamentous inclusions of tau are characteristic of more than 20 neurodegenerative diseases that are collectively termed tauopathies. Electron cryo-microscopy (cryo-EM) structures of tau amyloid filaments from human brain revealed that distinct tau folds characterise many different diseases. A lack of laboratory-based model systems to generate these structures has hampered efforts to uncover the molecular...

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Identifiers and source

Literature Corpus work
e2a44fe1-e324-5f98-94b6-03b102a7eb4c
DOI
10.1101/2021.12.16.472950
Open publication

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Assembly of recombinant tau into filaments identical to those of Alzheimer’s disease and chronic traumatic encephalopathyDOI 10.1101/2021.12.16.472950
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