Article

Accurate detection of shared genetic architecture from GWAS summary statistics in the small-sample context

2022-10-17

Abstract excerpt

Assessment of the genetic similarity between two phenotypes can provide insight into a common genetic aetiology and inform the use of pleiotropy-informed, cross-phenotype analytical methods to identify novel genetic associations. The genetic correlation is a well-known means of quantifying and testing for genetic similarity between traits, but its estimates are subject to comparatively large sampling error. This m...

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Literature Corpus work: a96dcfd8-8110-5e9d-af6b-cb2e7d1b501c
DOI: 10.1101/2022.10.13.512103

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