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Article

Accurate detection of shared genetic architecture from GWAS summary statistics in the small-sample context.

PLoS genetics - 1 Aug 2023

Willis Thomas W, Wallace Chris

Abstract excerpt

Assessment of the genetic similarity between two phenotypes can provide insight into a common genetic aetiology and inform the use of pleiotropy-informed, cross-phenotype analytical methods to identify novel genetic associations. The genetic correlation is a well-known means of quantifying and testing for genetic similarity between traits, but its estimates are subject to comparatively large sampling error. This...

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PMID: 37585442
DOI: 10.1371/journal.pgen.1010852
PMCID: PMC10461826

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