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Article

Studying gene and gene-environment effects of uncommon and common variants on continuous traits: a marker-set approach using gene-trait similarity regression.

American journal of human genetics - 12 Aug 2011

Tzeng Jung-Ying, Zhang Daowen, Pongpanich Monnat, Smith Chris, McCarthy Mark I, Sale Michèle M, Worrall Bradford B, Hsu Fang-Chi, Thomas Duncan C, Sullivan Patrick F

Abstract excerpt

Genomic association analyses of complex traits demand statistical tools that are capable of detecting small effects of common and rare variants and modeling complex interaction effects and yet are computationally feasible. In this work, we introduce a similarity-based regression method for assessing the main genetic and interaction effects of a group of markers on quantitative traits. The method uses genetic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21835306
DOI: 10.1016/j.ajhg.2011.07.007
PMCID: PMC3155192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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