Exploring Similarities and Differences Between Methods That Exploit Patterns of Local Genetic Correlation to Identify Shared Causal Loci Through Application to Genome-Wide Association Studies of Multiple Long Term Conditions.

Abstract excerpt

Genetic correlation analysis can provide useful insight into the shared genetic basis between traits or conditions of interest. However, most genome-wide analyses only inform about the degree of global (overall) genetic similarity and do not identify the specific genomic regions that give rise to this similarity. Identification of the key genomic regions contributing to shared genetic correlation between traits...

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