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Article

Statistical tests for detecting associations with groups of genetic variants: generalization, evaluation, and implementation.

European journal of human genetics : EJHG - 1 Jun 2013

Ferguson John, Wheeler William, Fu Yiping, Prokunina-Olsson Ludmila, Zhao Hongyu, Sampson Joshua

Abstract excerpt

With recent advances in sequencing, genotyping arrays, and imputation, GWAS now aim to identify associations with rare and uncommon genetic variants. Here, we describe and evaluate a class of statistics, generalized score statistics (GSS), that can test for an association between a group of genetic variants and a phenotype. GSS are a simple weighted sum of single-variant statistics and their cross-products. We...

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Identifiers

PMID: 23092956
DOI: 10.1038/ejhg.2012.220
PMCID: PMC3658182

Genes

GSS
MAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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