Article

Identifying the genetic basis and molecular mechanisms underlying phenotypic correlation between complex human traits using a gene-based approach

2021-02-10

Abstract excerpt

Phenotypic correlations between complex human traits have long been observed based on epidemiological studies. However, the genetic basis and underlying mechanisms are largely unknown. Here we developed a gene-based approach to measure genetic overlap between a pair of traits and to delineate the shared genes/pathways, through three steps: 1) translating SNP-phenotype association profile to gene-phenotype associat...

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Literature Corpus work: 9513e1bb-fdea-599f-a02a-e42cd742849e
DOI: 10.1101/2021.02.09.430368

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