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Article

Correlation-based tests for the formal comparison of polygenic scores in multiple populations.

PLoS genetics - 1 Apr 2024

Gunn Sophia, Lunetta Kathryn L

Abstract excerpt

Polygenic scores (PGS) are measures of genetic risk, derived from the results of genome wide association studies (GWAS). Previous work has proposed the coefficient of determination (R2) as an appropriate measure by which to compare PGS performance in a validation dataset. Here we propose correlation-based methods for evaluating PGS performance by adapting previous work which produced a statistical framework and...

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Identifiers

PMID: 38669290
DOI: 10.1371/journal.pgen.1011249
PMCID: PMC11078427

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