Back to search

Article

Cromolyn Platform Suppresses Fibrosis and Inflammation, Promotes Microglial Phagocytosis and Neurite Outgrowth

2021-08-26

Abstract excerpt

Neurodegenerative diseases are characterized by chronic neuroinflammation and may perpetuate ongoing fibrotic reactions within the central nervous system. In this report, RNA-seq analysis shows that administration of the pro-inflammatory cytokine TNF-α to HMC3 human microglia results in a robust upregulation of fibrosis-associated genes. Subsequent treatment with cromolyn and its fluorinated analogue F-cromolyn re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a95045af-917b-5e10-8f57-f4b12d63f7b9
DOI
10.21203/rs.3.rs-825684/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Cromolyn Platform Suppresses Fibrosis and Inflammation, Promotes Microglial Phagocytosis and Neurite OutgrowthDOI 10.21203/rs.3.rs-825684/v1
A cross-disease human microglial framework identifies disease-enriched subsets and tool compounds for microglial polarizationSemantic proximity
Disrupting microglial TGF-β signaling triggers region-specific pathology in the spinal cordSemantic proximity
Microglia Morphological Response to Mesenchymal Stromal Cell Extracellular Vesicles Demonstrates EV Therapeutic Potential for Modulating NeuroinflammationSemantic proximity
IFNγ alters the aberrant phenotype of α-synuclein-treated microglia reducing the detrimental impact of their secretome on dopaminergic neurons.Semantic proximity
A noble TGFβ biogenesis inhibitor exhibits both potent anti-fibrotic and anti-inflammatory capabilitiesSemantic proximity
A role for fibroblast and mural cell subsets in a nerve ligation model of neuropathic painSemantic proximity
A bottom-up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitorsSemantic proximity
The kynurenic acid analog SZR104 induces cytomorphological changes associated with the anti-inflammatory phenotype in cultured microglia.Semantic proximity
Transcriptomic analysis of melanoma cells reveals an association of α-synuclein with regulation of the inflammatory responseSemantic proximity
Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)Semantic proximity
PSMC5 regulates microglial polarization and activation in LPS-induced cognitive deficits and motor impairments by interacting with TLR4Semantic proximity
Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cellsSemantic proximity
Select a neighboring publication to make it the new centre.