Article

A bottom-up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitors

2024-06-17

Abstract excerpt

<h4>ABSTRACT</h4> Phagocytosis is an indispensable function of microglia, the brain professional phagocytes. Microglia are particularly efficient phagocytosing cells that undergo programmed cell death (apoptosis) in physiological conditions. However, mounting evidence suggests microglial phagocytosis dysfunction in multiple brain disorders. These observations prompted us to search for phagocytosis modulators (enh...

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Literature Corpus work: d58f74e2-a3dd-5bdf-9595-90f4b7b207e9
DOI: 10.1101/2024.06.17.599284

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A bottom-up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitorsDOI 10.1101/2024.06.17.599284Read

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