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Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells

2021-05-10

Abstract excerpt

<h4>Background</h4> Spinal cord motor neurons (MNs) from human iPS cells (iPSCs) have wide applications in disease modeling and therapeutic development for amyotrophic lateral sclerosis (ALS) and other MN-associated neurodegenerative diseases. We need highly efficient MN differentiation strategies for generating iPSC-derived disease models that closely recapitulate the genetic and phenotypic complexity of ALS. An...

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Literature Corpus work
8a942eaa-67ab-5780-b101-3d8f37da40fb
DOI
10.1101/2021.05.09.443325
Open publication

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Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cellsDOI 10.1101/2021.05.09.443325
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