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Article

The kynurenic acid analog SZR104 induces cytomorphological changes associated with the anti-inflammatory phenotype in cultured microglia.

Scientific reports - 13 Jul 2023

Szabo Melinda, Lajkó Noémi, Dulka Karolina, Barczánfalvi Gábor, Lőrinczi Bálint, Szatmári István, Mihály András, Vécsei László, Gulya Karoly

Abstract excerpt

We previously showed the anti-inflammatory effects of kynurenic acid (KYNA) and its brain-penetrable analog N-(2-(dimethylamino)ethyl)-3-(morpholinomethyl)-4-hydroxyquinoline-2-carboxamide (SZR104) both in vivo and in vitro. Here, we identified the cytomorphological effects of KYNA and SZR104 in secondary microglial cultures established from newborn rat forebrains. We quantitatively analyzed selected...

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PMID: 37443330
DOI: 10.1038/s41598-023-38107-8
PMCID: PMC10344911

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