Article

Transcriptomic analysis of melanoma cells reveals an association of α-synuclein with regulation of the inflammatory response

2023-12-23

Abstract excerpt

The Parkinson’s disease protein, alpha-synuclein (α-syn/ SNCA ), is highly expressed in neurons and melanomas. The goal of this study was to reveal the mechanism(s) of α-syn’s involvement in melanoma pathogenesis. To decipher the genes and pathways affected by α-syn, we conducted an RNA sequencing analysis of human SK-MEL-28 cells and several SK-MEL-28 SNCA -KO clones. We identified 1098 significantly up-regulat...

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Literature Corpus work: 5763825b-7d33-598b-a795-06f7a47d9630
DOI: 10.1101/2023.12.23.573196

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