Article

PSMC5 regulates microglial polarization and activation in LPS-induced cognitive deficits and motor impairments by interacting with TLR4

2023-07-07

Abstract excerpt

<h4>Background: </h4> Luteolin is a flavonoid found in high concentrations in celery and green pepper, and acts as a neuroprotectant. PSMC5 (proteasome 26S subunit, ATPase 5) protein levels were reduced after luteolin stimulation in activated microglia. We aimed to determine whether regulating PSMC5 expression could inhibit neuroinflammation, and investigate the underlying mechanisms. Methods BV2 microglia were t...

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Literature Corpus work: 1da4556c-e23e-56bf-8fd6-e06f3c4f4237
DOI: 10.21203/rs.3.rs-3140879/v1

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