Article

Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons

2024-11-26

Abstract excerpt

<title>Abstract</title> <p>Amyotrophic lateral sclerosis (ALS) lacks a specific biomarker, but is defined by relatively selective toxicity to motor neurons (MN). As others have highlighted, this offers an opportunity to develop a sensitive and specific biomarker based on detection of DNA released from dying MN within accessible biofluids. Here we have performed whole genome bisulfite sequencing (WGBS) of iPSC-der...

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Literature Corpus work: 1e39b2c1-de64-598e-a07f-e788cd54cc64
DOI: 10.21203/rs.3.rs-5397445/v1

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Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neuronsDOI 10.21203/rs.3.rs-5397445/v1Read

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