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Circulating cell-free DNA methylation profiles as noninvasive multiple sclerosis biomarkers: A proof-of-concept study

2025-02-20

Abstract excerpt

In chronic neurodegenerative diseases such as multiple sclerosis (MS), there is a critical unmet need for cost-effective non-invasive blood biomarkers to concurrently classify disease subtypes, monitor disability severity, and predict long-term progression. In this proof-of-concept study, we performed low-coverage whole-genome bisulfite sequencing (WGBS) on 75 plasma cell-free DNA (cfDNA) samples collected from a...

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Literature Corpus work
cc52eb34-9dea-59f2-8695-e9fdef86d1b2
DOI
10.1101/2025.02.14.25322180
Open publication

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Circulating cell-free DNA methylation profiles as noninvasive multiple sclerosis biomarkers: A proof-of-concept studyDOI 10.1101/2025.02.14.25322180
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