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Article

Distinctive cell-free DNA methylation characterizes presymptomatic genetic frontotemporal dementia.

Annals of clinical and translational neurology - 1 Mar 2024

Giannini Lucia A A, Boers Ruben G, van der Ende Emma L, Poos Jackie M, Jiskoot Lize C, Boers Joachim B, van IJcken Wilfred F J, Dopper Elise G, Pijnenburg Yolande A L, Seelaar Harro, Meeter Lieke H, van Rooij Jeroen G J, Scheper Wiep, Gribnau Joost, van Swieten John C

Abstract excerpt

OBJECTIVE: Methylation of plasma cell-free DNA (cfDNA) has potential as a marker of brain damage in neurodegenerative diseases such as frontotemporal dementia (FTD). Here, we study methylation of cfDNA in presymptomatic and symptomatic carriers of genetic FTD pathogenic variants, next to healthy controls. METHODS: cfDNA was isolated from cross-sectional plasma of 10 presymptomatic carriers (4 C9orf72, 4 GRN, and...

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Share to C9orf72 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38481040
DOI: 10.1002/acn3.51997
PMCID: PMC10963298

Genes

GRN
MAPT
TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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