Article
Methylome analysis of ALS patients and presymptomatic mutation carriers in blood cells.
Neurobiology of aging - 1 Aug 2022
Ruf Wolfgang P, Hannon Eilis, Freischmidt Axel, Grozdanov Veselin, Brenner David, Müller Kathrin, Knehr Antje, Günther Kornelia, Dorst Johannes, Ammerpohl Ole, Danzer Karin M, Mill Jonathan, Ludolph Albert C, Weishaupt Jochen H
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a fatal motoneuron disease with a monogenic cause in approximately 10% of cases. However, familial clustering of disease without inheritance in a Mendelian manner and the broad range of phenotypes suggest the presence of epigenetic mechanisms. Hence, we performed an epigenome-wide association study on sporadic, symptomatic and presymptomatic familial ALS cases with mutations...
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