Article
DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts.
PLoS genetics - 1 Jun 2013
Zhernakova Daria V, de Klerk Eleonora, Westra Harm-Jan, Mastrokolias Anastasios, Amini Shoaib, Ariyurek Yavuz, Jansen Rick, Penninx Brenda W, Hottenga Jouke J, Willemsen Gonneke, de Geus Eco J, Boomsma Dorret I, Veldink Jan H, van den Berg Leonard H, Wijmenga Cisca, den Dunnen Johan T, van Ommen Gert-Jan B, 't Hoen Peter A C, Franke Lude
Abstract excerpt
Many disease-associated variants affect gene expression levels (expression quantitative trait loci, eQTLs) and expression profiling using next generation sequencing (NGS) technology is a powerful way to detect these eQTLs. We analyzed 94 total blood samples from healthy volunteers with DeepSAGE to gain specific insight into how genetic variants affect the expression of genes and lengths of 3'-untranslated regions...
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