Article
Motor impairment and aberrant production of neurochemicals in human alpha-synuclein A30P+A53T transgenic mice with alpha-synuclein pathology.
Brain research - 23 Jan 2009
Ikeda Masaki, Kawarabayashi Takeshi, Harigaya Yasuo, Sasaki Atsushi, Yamada Shuichi, Matsubara Etsuro, Murakami Tetsuro, Tanaka Yuya, Kurata Tomoko, Wuhua Xu, Ueda Kenji, Kuribara Hisashi, Ikarashi Yasushi, Nakazato Yoichi, Okamoto Koichi, Abe Koji, Shoji Mikio
Abstract excerpt
Missense point mutations, duplication and triplication in the alpha-synuclein (alphaSYN) gene have been identified in familial Parkinson's disease (PD). Familial and sporadic PD show common pathological features of alphaSYN pathologies, e.g., Lewy bodies (LBs) and Lewy neurites (LNs), and a loss of dopaminergic neurons in the substantia nigra that leads to motor disturbances. To elucidate the mechanism of...
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