Article

SREBP-dependent regulation of lipid homeostasis is required for progression and growth of pancreatic ductal adenocarcinoma

2024-02-08

Abstract excerpt

<h4>ABSTRACT</h4> Metabolic reprogramming is a necessary component of oncogenesis and cancer progression that solid tumors undergo when their growth outstrips local nutrient supply. The supply of lipids such as cholesterol and fatty acids is required for continued tumor cell proliferation, and oncogenic mutations stimulate de novo lipogenesis to support tumor growth. Sterol regulatory element-binding protein (SRE...

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Identifiers and source

Literature Corpus work: a90763bd-db1b-5862-a056-b3bb6c9b278e
DOI: 10.1101/2024.02.04.578802

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