Article
Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression.
Cell reports - 22 May 2014
Kinsey Conan, Balakrishnan Vijaya, O'Dell Michael R, Huang Jing Li, Newman Laurel, Whitney-Miller Christa L, Hezel Aram F, Land Hartmut
Abstract excerpt
Mutations in p53 and RAS potently cooperate in oncogenic transformation, and correspondingly, these genetic alterations frequently coexist in pancreatic ductal adenocarcinoma (PDA) and other human cancers. Previously, we identified a set of genes synergistically activated by combined RAS and p53 mutations as frequent downstream mediators of tumorigenesis. Here, we show that the synergistically activated gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.