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Targeting PIKfyve-driven lipid metabolism in pancreatic cancer

23 Apr 2025

Abstract excerpt

Abstract Pancreatic ductal adenocarcinoma (PDAC) subsists in a nutrient-deregulated microenvironment, making it particularly susceptible to treatments that interfere with cancer metabolism 1,2 . For example, PDAC uses, and is dependent on, high levels of autophagy and other lysosomal processes 3–5 . Although targeting these pathways has shown potential in preclinical studies, progress has been hampered by the...

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PMID: 40269157
DOI: 10.1038/s41586-025-08917-z

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